PROPERTIES AND MODELING OF GWAS WHEN COMPLEX DISEASE RISK IS DUE TO NON-COMPLEMENTING, DELETERIOUS MUTATIONS IN GENES OF LARGE EFFECT.

Properties and modeling of GWAS when complex disease risk is due to non-complementing, deleterious mutations in genes of large effect.

Current genome-wide association studies (GWAS) have high power to detect intermediate frequency SNPs making modest contributions to complex disease, but they are underpowered to detect rare alleles of large effect (RALE).This has led to speculation that the bulk of variation for most complex diseases is due to RALE.One concern with Comment on "Theo

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Nature in the Eye of the Beholder: A Case Study for Cultural Humility as a Strategy to Broaden Participation in STEM

Science, technology, engineering, and math (STEM) disciplines suffer from chronically low participation of women and underrepresented minorities.Diversity enhancement initiatives frequently attempt to mitigate skill deficits such as math skills in an attempt to improve preparedness of these students.However, such interventions do not address cultur

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Coupling Tank Model and Lars-Weather Generator in Assessments of the Impacts of Climate Change on Water Resources

With the aim of assessing the impact of climate change on surface water resources, a conceptual rainfall-runoff model (the tank model) was coupled with LARS-WG as Analysis on the imbalance of population flow network during the Spring Festival travel rush in China in 2015. a weather generator model.The downscaled daily rainfall, temperature, and eva

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Lifestyle patterns, nutritional, and metabolic syndrome determinants in a sample of the older Iranian population

Abstract Background Chronic diseases and metabolic disorders are prevalent health concerns that often escalate with increasing age and thus affect older individuals.The proportion of the elderly population in Iran increased from 7.22% in 2006 to 12.0% in 2023.The current study aimed to evaluate lifestyle patterns and lifestyle risk factors among pa

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